Gene-environment interaction in posttraumatic stress disorder
نویسندگان
چکیده
منابع مشابه
Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Stud
The FKBP5 gene, a glucocorticoid receptor (GR)-regulating co-chaperone of stress proteins, is of special interest because of its role in hypothalamic-pituitary-adrenal (HPA)-axis regulation. However, studies finding a genetic relationship between posttraumatic stress disorder (PTSD) and the FKBP5 gene have failed to distinguish between the development and persistence of PTSD, thereby limiting t...
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Around 75% of civilians have experienced at least one traumatic event in their lives, and this number is considerably higher in many parts of the world, as well as in military veterans and first responders. Of those exposed to trauma, 15-25% will develop Posttraumatic Stress Disorder (PTSD). PTSD extracts enormous economic, health, and quality of life cost. Thus, it is critical to underst...
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Post-traumatic stress disorder (PTSD) is a disorder which might occur in subjects after experiencing a traumatic life event. The underlying etiology of this disorder is still unknown but malfunction of the brain’s anxiety network is discussed. Therefore, neuroscience research might give new insights about the neurobiological mechanisms of PTSD. The talk will give a systematic overview abo...
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Among 590 hurricane-exposed Floridians, the serotonin transporter genotype, 5-HTTLPR, was associated with decreased risk of posttraumatic stress disorder (PTSD) in county-level low-risk environments (low crime/unemployment rates) but increased PTSD in county-level high-risk environments (Koenen et al., 2009). These results suggest genetic vulnerability to PTSD may be affected by environmental s...
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Patients with posttraumatic stress disorder (PTSD) exhibit an increased state of inflammation. Various animal models for PTSD have shown some of the same immune imbalances as have been shown in human subjects with PTSD, and some of these studies are discussed in this review. However, animal studies can only indirectly implicate immune involvement in PTSD in humans. This review of mainly studies...
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ژورنال
عنوان ژورنال: European Archives of Psychiatry and Clinical Neuroscience
سال: 2008
ISSN: 0940-1334,1433-8491
DOI: 10.1007/s00406-007-0787-2